Cold stress protein RBM3 responds to hypothermia and is associated with good stroke outcome

Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons

Extremely mild hypothermia to 36.0 °C is not thought to appreciably differ clinically from 37.0 °C. However, it is possible that 36.0 °C stimulates highly sensitive hypothermic signaling mechanism(s) and alters biochemistry. To the best of our knowledge, no such ultra-sensitive pathway/mechanisms have been described. Here we show that cold stress protein RNA binding motif 3 (RBM3) increases in ...

Delayed combination therapy of local brain hypothermia and decompressive craniectomy on acute stroke outcome in rat

Objective(s):Hypothermia and decompressive craniectomy (DC) have been shown to be neuroprotective. This study was designed to evaluate neuroprotective effects of delayed singular or combination of DC and local hypothermia on stroke. Materials and Methods: Cerebral ischemia was induced in 48 Wistar rats assigned to 4 groups: control, decompressive craniectomy (DC), local hypothermia (LH), combin...

The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome.

BACKGROUND AND PURPOSE Increased circulating endothelial progenitor cells (EPC) have been associated with a low cardiovascular risk and may be involved in endothelial cell regeneration. The present study was designed to evaluate the prognostic value of EPC in acute ischemic stroke. METHODS Forty-eight patients with a first-ever nonlacunar ischemic stroke were prospectively included in the stu...

RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3

Cooling and hypothermia are profoundly neuroprotective, mediated, at least in part, by the cold shock protein, RBM3. However, the neuroprotective effector proteins induced by RBM3 and the mechanisms by which mRNAs encoding cold shock proteins escape cooling-induced translational repression are unknown. Here, we show that cooling induces reprogramming of the translatome, including the upregulati...

Human Physiological Responses to Cold Stress and Hypothermia